Atrial Fibrillation
July 2019 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Atrial Fibrillation abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Atrial Fibrillation. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Atrial Fibrillation. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Atrial Fibrillation every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Association between gene variants and the recurrence of atrial fibrillation: An updated meta-analysis.
Authors:Jiang T, Wang YN, Qu Q, Qi TT, Chen YD, Qu J
Institution:Department of Cardiovascular Medicine. Institute of Clinical Pharmacy, Central South University, Changsha. Liberation Army, Beijing, People's Republic of China. Institute of Clinical Pharmacy, Central South University, Changsha.
Journal:Medicine (Baltimore). 2019 Jun;98(23):e15953. doi: 10.1097/MD.0000000000015953.

2:Clinical Outcomes of Antithrombotic Strategies for Patients with Atrial Fibrillation After Percutaneous Coronary Intervention.
Authors:Gao X, Ge Z, Kong X, Wang Z, Zuo G, Wang F, Chen S, Zhang J
Institution:Department of Cardiology, Nanjing First Hospital, Nanjing Medical University.
Journal:Int Heart J. 2019 May 30;60(3):546-553. doi: 10.1536/ihj.18-464. Epub 2019 May 17.

3:The Effect of Acupressure on Cardiac Rhythm and Heart Rate Among Patients With Atrial Fibrillation: The Relationship Between Heart Rate and Fatigue.
Authors:Ceyhan O, Tasci S, Elmali F, Dogan A
Journal:Altern Ther Health Med. 2019 Jan;25(1):12-19.

4:Atrial Fibrillation in Heart Failure: Left Atrial Appendage Management.
Authors:Ellis CR, Kanagasundram AN
Institution:Left Atrial Appendage Program, Vanderbilt University Medical Center, 5414 Medical Center East, 1211 21st Avenue South, Nashville, TN 37232-8802, USA. Electronic address: 37232-8802, USA.
Journal:Cardiol Clin. 2019 May;37(2):241-249. doi: 10.1016/j.ccl.2019.01.009. Epub 2019 Feb 13.

5:Prediction and Management of Recurrences after Catheter Ablation in Atrial Fibrillation and Heart Failure.
Authors:El-Harasis MA, DeSimone CV, Yao X, Noseworthy PA
Institution:Division of Internal Medicine, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA. Rochester, MN 55905, USA. Research, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA; Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA. Rochester, MN 55905, USA; Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA. Electronic address:
Journal:Cardiol Clin. 2019 May;37(2):221-230. doi: 10.1016/j.ccl.2019.01.010. Epub 2019 Feb 12.

6:Novel Ablation Approaches for Challenging Atrial Fibrillation Cases (Mapping, Irrigation, and Catheters).
Authors:Bhardwaj R, Koruth JS
Institution:Loma Linda University, 11234 Anderson Street, Room 4404, Loma Linda, CA 92354, USA. Sinai Medical Center, One Gustave L Levy Place - Box 1030, New York, NY 10029, USA. Electronic address:
Journal:Cardiol Clin. 2019 May;37(2):207-219. doi: 10.1016/j.ccl.2019.01.012.

7:Atrial Fibrillation Ablation Should Be First-Line Therapy in Heart Failure Patients: CON.
Authors:Khaji A, Hanley C, Kowey PR
Institution:Lankenau Heart Institute, 100 East Lancaster Avenue, Wynnewood, PA 19087, USA. Electronic address: Philadelphia, PA 19107, USA.
Journal:Cardiol Clin. 2019 May;37(2):197-206. doi: 10.1016/j.ccl.2019.01.005.

8:Atrial Fibrillation Ablation Should Be First-line Therapy in Patients with Heart Failure Reduced Ejection Fraction.
Authors:Agasthi P, Tseng A, Lee JZ, Mulpuru SK
Institution:Department of Cardiovascular Diseases, Mayo Clinic, 5777 East Mayo Boulevard, Phoenix, AZ 85054, USA. AZ 85054, USA. Phoenix, AZ 85054, USA. Rochester, MN 55905, USA. Electronic address:
Journal:Cardiol Clin. 2019 May;37(2):185-195. doi: 10.1016/j.ccl.2019.01.004. Epub 2019 Feb 14.

9:Pathophysiology of Atrial Fibrillation and Heart Failure: Dangerous Interactions.
Authors:Sugumar H, Nanayakkara S, Prabhu S, Voskoboinik A, Kaye DM, Ling LH, Kistler PM
Institution:Department of clinical research, The Baker Heart and Diabetes Institute, 75 Commercial road, Melbourne, Victoria, 3004 Australia; Department of Cardiology, The Alfred Hospital, 55 Commercial road, Melbourne, Victoria, 3004, Australia; Department of Cardiology, Royal Melbourne Hospital, 300 Grattan Street, Parkville, Victoria 3050, Australia; Department of Medicine, University of Melbourne, Grattan Street, Parkville, Victoria, 3010, Australia.; Department of clinical research, The Baker Heart and Diabetes Institute, 75 Commercial road, Melbourne, Victoria, 3004 Australia; Department of Cardiology, The Alfred Hospital, 55 Commercial road, Melbourne, Victoria, 3004, Australia; Department of Medicine, Monash University, Victoria, 3800, Australia.; Department of clinical research, The Baker Heart and Diabetes Institute, 75 Commercial road, Melbourne, Victoria, 3004 Australia; Department of Cardiology, The Alfred Hospital, 55 Commercial road, Melbourne, Victoria, 3004, Australia; Department of Medicine, University of Melbourne, Grattan Street, Parkville, Victoria, 3010, Australia. Electronic address:
Journal:Cardiol Clin. 2019 May;37(2):131-138. doi: 10.1016/j.ccl.2019.01.002. Epub 2019 Feb 20.

10:Edoxaban for the prevention of stroke in patients with atrial fibrillation.
Authors:Cervantes CE, Merino JL, Barrios V
Institution:a Cardiology Service, Unidad de electrofisiologia cardiaca robotizada , Hospital Universitario La Paz , Madrid , Spain. Universitario La Paz , Madrid , Spain.
Journal:Expert Rev Cardiovasc Ther. 2019 Apr;17(4):319-330. doi: 10.1080/14779072.2019.1598263. Epub 2019 Mar 27.

11:Antithrombotic Therapy after Acute Coronary Syndrome or PCI in Atrial Fibrillation.
Authors:Lopes RD, Heizer G, Aronson R, Vora AN, Massaro T, Mehran R, Goodman SG, Windecker S, Darius H, Li J, Averkov O, Bahit MC, Berwanger O, Budaj A, Hijazi Z, Parkhomenko A, Sinnaeve P, Storey RF, Thiele H, Vinereanu D, Granger CB, Alexander JH
Institution:From the Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC (R.D.L., G.H., A.N.V., T.M., C.B.G., J.H.A.); Bristol-Myers Squibb, Princeton, NJ (R.A., J.L.); Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, and Cardiovascular Research Foundation, New York (R.M.); Canadian VIGOUR Centre, University of Alberta, Edmonton (S.G.G.), and the Terrence Donnelly Heart Centre, St. Michael's Hospital, University of Toronto, Toronto (S.G.G.) - both in Canada; Swiss Cardiovascular Center, Bern, Switzerland (S.W.); Vivantes Neukoelln Medical Center, Berlin (H.D.), and Heart Center Leipzig, Department of Internal Medicine-Cardiology, University of Leipzig, Leipzig (H.T.) - both in Germany; Pirogov Russian National Research Medical University, Moscow (O.A.); Instituto de Neurologia Cognitiva (INECO) Neurociencias Orono, Fundacion INECO, Rosario, Argentina (M.C.B.); Hospital Israelita Albert Einstein, Sao Paulo (O.B.); Postgraduate Medical School, Grochowski Hospital, Warsaw, Poland (A.B.); the Department of Medical Sciences, Cardiology, and Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden (Z.H.); the National Scientific Center, Strazhesko Institute of Cardiology, Kiev, Ukraine (A.P.); University Hospitals Leuven, University of Leuven, Leuven, Belgium (P.S.); the Department of Infection, Immunity, and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom (R.F.S.); and University of Medicine and Pharmacy Carol Davila, University and Emergency Hospital, Bucharest, Romania (D.V.).
Journal:N Engl J Med. 2019 Apr 18;380(16):1509-1524. doi: 10.1056/NEJMoa1817083. Epub 2019 Mar 17.

12:Early or Delayed Cardioversion in Recent-Onset Atrial Fibrillation.
Authors:Pluymaekers NAHA, Dudink EAMP, Luermans JGLM, Meeder JG, Lenderink T, Widdershoven J, Bucx JJJ, Rienstra M, Kamp O, Van Opstal JM, Alings M, Oomen A, Kirchhof CJ, Van Dijk VF, Ramanna H, Liem A, Dekker LR, Essers BAB, Tijssen JGP, Van Gelder IC, Crijns HJGM
Institution:From the Departments of Cardiology (N.A.H.A.P., E.A.M.P.D., J.G.L.M.L., H.J.G.M.C.) and Clinical Epidemiology and Medical Technology Assessment (B.A.B.E.), the Cardiovascular Research Institute Maastricht (N.A.H.A.P., E.A.M.P.D., J.G.L.M.L., H.J.G.M.C.), Maastricht University Medical Center, Maastricht, VieCuri Medical Center Noord-Limburg, Venlo (J.G.M.), Zuyderland Medical Center, Heerlen (T.L.), Elisabeth-TweeSteden Hospital, Tilburg (J.W.), Diakonessen Hospital, Utrecht (J.J.J.B.), University of Groningen, Groningen (M.R., I.C.V.G.), VU University Medical Center Amsterdam (O.K.) and Academic Medical Center (J.G.P.T), Amsterdam, Medical Spectrum Twente, Enschede (J.M.V.O.), Amphia Hospital, Breda (M.A.), Antonius Hospital, Sneek (A.O.), Alrijne Hospital, Leiderdorp (C.J.K.), St. Antonius Hospital, Nieuwegein (V.F.V.D.), Haga Teaching Hospital, The Hague (H.R.), St. Franciscus Gasthuis, Rotterdam (A.L.), and Catharina Hospital, Eindhoven (L.R.D) - all in the Netherlands.
Journal:N Engl J Med. 2019 Apr 18;380(16):1499-1508. doi: 10.1056/NEJMoa1900353. Epub 2019 Mar 18.

13:Effect of Catheter Ablation vs Antiarrhythmic Medication on Quality of Life in Patients With Atrial Fibrillation: The CAPTAF Randomized Clinical Trial.
Authors:Blomstrom-Lundqvist C, Gizurarson S, Schwieler J, Jensen SM, Bergfeldt L, Kenneback G, Rubulis A, Malmborg H, Raatikainen P, Lonnerholm S, Hoglund N, Mortsell D
Institution:Department of Medical Science and Cardiology, Uppsala University, Uppsala, Sweden. Sahlgrenska Academy, University of Gothenburg, Sweden. University, Umea, Sweden. Sahlgrenska Academy, University of Gothenburg, Sweden. Sahlgrenska Academy, University of Gothenburg, Sweden. Sweden. Finland. Sweden. University, Umea, Sweden. Sweden.
Journal:JAMA. 2019 Mar 19;321(11):1059-1068. doi: 10.1001/jama.2019.0335.

14:Anticoagulation in atrial fibrillation and cognitive decline: A systematic review and meta-analysis.
Authors:Zeng D, Jiang C, Su C, Tan Y, Wu J
Institution:Department of Ultrasonic Medicine, First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Journal:Medicine (Baltimore). 2019 Feb;98(7):e14499. doi: 10.1097/MD.0000000000014499.

15:Interaction of obesity and atrial fibrillation: an overview of pathophysiology and clinical management.
Authors:Pouwels S, Topal B, Knook MT, Celik A, Sundbom M, Ribeiro R, Parmar C, Ugale S
Institution:a Department of Surgery , Haaglanden Medical Center , The Hague , The Netherlands. Netherlands. Lisbon , Portugal.
Journal:Expert Rev Cardiovasc Ther. 2019 Mar;17(3):209-223. doi: 10.1080/14779072.2019.1581064. Epub 2019 Feb 20.

16:Concerns about clinical efficacy and safety of warfarin in diabetic patients with atrial fibrillation.
Authors:Yamagishi SI
Institution:Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Kurume University School of Medicine, Kurume, 830-0011, Japan.
Journal:Cardiovasc Diabetol. 2019 Jan 28;18(1):12. doi: 10.1186/s12933-019-0818-0.

17:Improving the Prescription of Oral Anticoagulants in Atrial Fibrillation: A Systematic Review.
Authors:Pritchett RV, Bem D, Turner GM, Thomas GN, Clarke JL, Fellows R, Lane DA, Jolly K
Institution:Institute of Applied Health Research, University of Birmingham, Birmingham, United Kingdom. United Kingdom. United Kingdom. United Kingdom. United Kingdom. United Kingdom. United Kingdom. University, Aalborg, Denmark. United Kingdom.
Journal:Thromb Haemost. 2019 Feb;119(2):294-307. doi: 10.1055/s-0038-1676835. Epub 2019 Jan 22.

18:Catheter ablation of atrial fibrillation-A key role in heart failure therapy?
Authors:Tose Costa Paiva B, Fischer TH, Brachmann J, Busch S
Institution:II. Medizinische Klinik, Kardiologie, Angiologie, Pneumologie, Klinikum Coburg, Coburg, Germany.
Journal:Clin Cardiol. 2019 Mar;42(3):400-405. doi: 10.1002/clc.23150. Epub 2019 Feb 12.

19:Hypertrophic Cardiomyopathy in Patients with Atrial Fibrillation: Prevalence and Associated Stroke Risks in a Nationwide Cohort Study.
Authors:Jung H, Yang PS, Sung JH, Jang E, Yu HT, Kim TH, Uhm JS, Kim JY, Pak HN, Lee MH, Lip GYH, Joung B
Institution:Division of Cardiology, Department of Internal Medicine, Yonsei University College of Medicine, Severance Cardiovascular Hospital, Yonsei University, Seoul, Republic of Korea.; Department of Cardiology, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea.; Liverpool Centre for Cardiovascular Science, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, Merseyside, United Kingdom.; Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
Journal:Thromb Haemost. 2019 Feb;119(2):285-293. doi: 10.1055/s-0038-1676818. Epub 2019 Jan 2.

20:CHA2DS2-VASc score predicts atrial fibrillation recurrence after cardioversion: Systematic review and individual patient pooled meta-analysis.
Authors:Vitali F, Serenelli M, Airaksinen J, Pavasini R, Tomaszuk-Kazberuk A, Mlodawska E, Jaakkola S, Balla C, Falsetti L, Tarquinio N, Ferrari R, Squeri A, Campo G, Bertini M
Institution:Cardiovascular Center, Azienda Ospedaliero-Universitaria di Ferrara, Ferrara, Italy. Italy.
Journal:Clin Cardiol. 2019 Mar;42(3):358-364. doi: 10.1002/clc.23147. Epub 2019 Feb 11.

21:Anticoagulation in patients with atrial fibrillation and heart failure: Insights from the NCDR PINNACLE-AF registry.
Authors:Contreras JP, Hong KN, Castillo J, Marzec LN, Hsu JC, Cannon CP, Yang S, Maddox TM
Institution:Mount Sinai School of Medicine, Division of Cardiology, New York, New York. California. Colorado.
Journal:Clin Cardiol. 2019 Mar;42(3):339-345. doi: 10.1002/clc.23142. Epub 2019 Jan 30.

22:Predictors of improvement in arrhythmia-specific symptoms and health-related quality of life after catheter ablation of atrial fibrillation.
Authors:Barmano N, Charitakis E, Karlsson JE, Nystrom FH, Walfridsson H, Walfridsson U
Institution:Department of Internal Medicine, County Hospital Ryhov, Jonkoping, Sweden. Sweden. Sweden. Sweden. Sweden. Sweden. Sweden.
Journal:Clin Cardiol. 2019 Feb;42(2):247-255. doi: 10.1002/clc.23134. Epub 2018 Dec 21.

23:Gender Differences in Atrial Fibrillation: A Review of Epidemiology, Management, and Outcomes.
Authors:Westerman S, Wenger N
Institution:School of Medicine, Emory University, 1639 Pierce Drive, WMB 308 Atlanta, GA 30322, United States. 30322, United States.
Journal:Curr Cardiol Rev. 2019;15(2):136-144. doi: 10.2174/1573403X15666181205110624.

24:Catheter Ablation Versus Medical Therapy for Atrial Fibrillation in Patients With Heart Failure: A Meta-Analysis of Randomised Controlled Trials.
Authors:Virk SA, Bennett RG, Chow C, Sanders P, Kalman JM, Thomas S, Kumar S
Institution:Department of Cardiology, Westmead Hospital, Sydney, NSW, Australia. Applied Research Centre, University of Sydney, Sydney, NSW, Australia. Adelaide, Adelaide, SA, Australia. Melbourne, Vic, Australia. Applied Research Centre, University of Sydney, Sydney, NSW, Australia. Electronic address:
Journal:Heart Lung Circ. 2019 May;28(5):707-718. doi: 10.1016/j.hlc.2018.10.022. Epub 2018 Nov 17.

25:Comparative safety and effectiveness of dabigatran vs. rivaroxaban and apixaban in patients with non-valvular atrial fibrillation: a retrospective study from a large healthcare system.
Authors:Villines TC, Ahmad A, Petrini M, Tang W, Evans A, Rush T, Thompson D, Oh K, Schwartzman E
Institution:Department of Medicine, Cardiology Service, Walter Reed National Military Medical Center, 8901 Wisconsin Avenue, Rockville, MD, USA. Changkat Semantan, Damansara Height, Kuala Lumpur, Malaysia. USA. USA.
Journal:Eur Heart J Cardiovasc Pharmacother. 2019 Apr 1;5(2):80-90. doi: 10.1093/ehjcvp/pvy044.

26:Is it safe to stop oral anticoagulation after catheter ablation for atrial fibrillation?
Authors:Romero J, Avendano R, Diaz JC, Taveras J, Lupercio F, Di Biase L
Institution:a Department of Cardiology , Montefiore Medical Center, Albert Einstein College of Medicine , Bronx , NY , USA.
Journal:Expert Rev Cardiovasc Ther. 2019 Jan;17(1):31-41. doi: 10.1080/14779072.2019.1550718. Epub 2018 Dec 18.

27:Atrial Fibrillation and Heart Failure in Women.
Authors:Madan N, Itchhaporia D, Albert CM, Aggarwal NT, Volgman AS
Institution:Department of Medicine, Cardiology Division, Rush University Medical Center, 1653 West Congress Parkway, Chicago, IL 60612, USA. of California, Irvine, 520 Superior Avenue, Newport Beach, CA 92663, USA. 75 Francis Street Towers 3a, Boston, MA 02115, USA. University Medical Center, 1750 W. Harrison, Suite 1000, Chicago, IL 60612, USA. W. Harrison Street, Room 1159, Chicago, IL 60612, USA. Electronic address:
Journal:Heart Fail Clin. 2019 Jan;15(1):55-64. doi: 10.1016/j.hfc.2018.08.006. Epub 2018 Oct 24.

28:Safety and efficacy of direct acting oral anticoagulants and vitamin K antagonists in nonvalvular atrial fibrillation - a network meta-analysis of real-world data.
Authors:Hirschl M, Kundi M
Institution:1 Department of Angiology, Hanusch Hospital, Vienna, Austria.
Journal:Vasa. 2019 Mar;48(2):134-147. doi: 10.1024/0301-1526/a000746. Epub 2018 Nov 5.

29:Patients' experiences 1-6 months after atrial fibrillation ablation: An holistic perspective.
Authors:Bergtun S, Oterhals K, Fridlund B
Institution:Department of Heart Disease, Haukeland University Hospital, Bergen, Norway.
Journal:J Adv Nurs. 2019 Jan;75(1):150-160. doi: 10.1111/jan.13843. Epub 2018 Oct 5.

30:Safety and efficacy of cryoballoon ablation for the treatment of atrial fibrillation in elderly patients.
Authors:Abdin A, Yalin K, Lyan E, Sawan N, Liosis S, Meyer-Saraei R, Elsner C, Lange SA, Heeger CH, Eitel C, Eitel I, Tilz RR
Institution:University Heart Center Luebeck, Medical Clinic II (Department of Cardiology, Angiology and Intensive Care Medicine), University Hospital Schleswig-Holstein, Ratzeburger Allee 160, 23538, Luebeck, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Luebeck, Luebeck, Germany.; Department of Cardiology, Faculty of Medicine, Usak University, Usak, Turkey.
Journal:Clin Res Cardiol. 2019 Feb;108(2):167-174. doi: 10.1007/s00392-018-1336-x. Epub 2018 Sep 5.

31:Real-world clinical evidence on rivaroxaban, dabigatran, and apixaban compared with vitamin K antagonists in patients with nonvalvular atrial fibrillation: a systematic literature review.
Authors:Briere JB, Bowrin K, Coleman C, Fauchier L, Levy P, Folkerts K, Toumi M, Taieb V, Millier A, Wu O
Institution:a Health Economist , Berlin , Germany. Hartford , Connecticut , USA. Rabelais , Tours , France. London , UK.
Journal:Expert Rev Pharmacoecon Outcomes Res. 2019 Feb;19(1):27-36. doi: 10.1080/14737167.2018.1518134. Epub 2018 Sep 19.

32:Exercise in individuals with atrial fibrillation.
Authors:Myrstad M, Malmo V, Ulimoen SR, Tveit A, Loennechen JP
Institution:Department of Medical Research, Baerum Hospital, Vestre Viken Hospital Trust, Gjettum, Norway. University of Science and Technology, Trondheim, Norway. Gjettum, Norway. Oslo, Norway. Gjettum, Norway. University of Science and Technology, Trondheim, Norway.
Journal:Clin Res Cardiol. 2019 Apr;108(4):347-354. doi: 10.1007/s00392-018-1361-9. Epub 2018 Aug 22.

33:Primary stroke prevention: a paradigm shift focusing on silent paroxysmal atrial fibrillation.
Authors:Schattner A
Institution:From the Faculty of Medicine, Hebrew University and Hadassah Medical School, Jerusalem, Israel.
Journal:QJM. 2019 Apr 1;112(4):247-249. doi: 10.1093/qjmed/hcy130.

34:Comparison of all-cause, stroke, and bleed-specific healthcare resource utilization among patients with non-valvular atrial fibrillation (NVAF) and newly treated with dabigatran or warfarin.
Authors:Song X, Gandhi P, Gilligan AM, Arora P, Wang C, Henriques C, Sander S, Smith DM
Institution:a Department for Truven Health Analytics, an IBM Company , Cambridge , MA , USA. USA. USA. USA. USA.
Journal:Expert Rev Pharmacoecon Outcomes Res. 2019 Apr;19(2):213-222. doi: 10.1080/14737167.2017.1347041. Epub 2017 Jul 3.

35:Does Sotalol Still Have a Role in the Management of Arrhythmias?
Authors:Semasinghe Bandaralage SP, Nirthanan S, Niranjan S
Institution:Gold Coast Hospital and Health Service, Southport, Queensland, Australia. Australia.
Journal:Am J Ther. 2019 Jan/Feb;26(1):e161-e169. doi: 10.1097/MJT.0000000000000507.

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