Atrial Fibrillation
February 2018 Issue

Nearly every major medical breakthrough over the past 50 years can be attributed to new discoveries that were made possible through meticulous biomedical research. Many diseases and conditions that previously took a heavy toll on patients in terms of both morbidity and mortality are now either treatable or preventable thanks in large part to painstaking research that expanded the frontiers of scientific knowledge and moved the most promising basic research developments into tangible health benefits through human clinical trails. Ongoing research is also the key that will open the door to additional major medical advances and breakthroughs in the future.

Our staff at Medifocus is committed to keeping our subscribers to the Medifocus Digest Alert on Atrial Fibrillation abreast of the latest new research developments that have recently been published in the medical literature for this condition. In this issue of the Digest Alert, you will find a focused list of hand-picked journal article references that represent the latest advances in basic and clinical research for Atrial Fibrillation. These articles represent the current state-of-the-art of the research that will hopefully lead to additional major advances and breakthroughs in the clinical management of Atrial Fibrillation. You can access the summaries of each article referenced below by simply clicking on the article Title.

We will continue to update you with the latest scientific and clinical developments through the Medifocus Digest Alert on Atrial Fibrillation every 3 months. Thank you for your ongoing subscription to this publication.

Elliot Jacob, Ph.D.
Vice-President - Content, Inc.

1:Chinese herbal medicine for patients with atrial fibrillation: protocol for a systematic review and meta-analysis.
Authors:Cai X, Wang Y, Li Z, Zhang Y, Wang D, Yan X
Institution:Guangzhou University of Chinese Medicine. Guangdong Provincial Hospital of Chinese Medicine. China. Guangdong Provincial Hospital of Chinese Medicine.
Journal:Medicine (Baltimore). 2017 Dec;96(50):e9228. doi: 10.1097/MD.0000000000009228.

2:Association of atrial fibrillation and cancer: Analysis from two large population-based case-control studies.
Authors:Saliba W, Rennert HS, Gronich N, Gruber SB, Rennert G
Institution:Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel. Technology, Haifa, Israel. Center, Haifa, Israel. Technology, Haifa, Israel. Center, Haifa, Israel. Technology, Haifa, Israel. Angeles, California, United States of America. Southern California, Los Angeles, California, United States of America. Center, Haifa, Israel. Technology, Haifa, Israel.
Journal:PLoS One. 2018 Jan 11;13(1):e0190324. doi: 10.1371/journal.pone.0190324. eCollection 2018.

3:Can catheter ablation reduce the incidence of thromboembolic events in patients with atrial fibrillation?: Protocol for a systematic review and meta-analysis.
Authors:Liu M, Wang Y, Chen X, Li X, Zhuang X, Wang L
Institution:Department of Cardiology, The First Affiliated Hospital, Sun Yet-sen University. Guangzhou University of Chinese Medicine. Guangzhou University of Chinese Medicine.
Journal:Medicine (Baltimore). 2017 Dec;96(48):e8479. doi: 10.1097/MD.0000000000008479.

4:The safety and efficacy of hybrid ablation for the treatment of atrial fibrillation: A meta-analysis.
Authors:Jiang YQ, Tian Y, Zeng LJ, He SN, Zheng ZT, Shi L, Wang YJ, Wang YX, Yin XD, Liu XQ, Yang XC, Liu XP
Institution:Cardiac Arrhythmias Section, Heart Center, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.; Department of Cardiology, Beijing Lu-He Hospital, Capital Medical University, Beijing, China.
Journal:PLoS One. 2018 Jan 3;13(1):e0190170. doi: 10.1371/journal.pone.0190170. eCollection 2018.

5:Catheter ablation versus rate control in patients with atrial fibrillation and heart failure: A multicenter study.
Authors:Geng J, Zhang Y, Wang Y, Cao L, Song J, Wang B, Song W, Li J, Xu W
Institution:aDepartment of Cardiology, Huai'an First People's Hospital, Nanjing Medical UniversitybDepartment of Cardiology, Huai'an Second People's Hospital, the Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, JiangsucDepartment of Cardiology, Nanjing Jiangning HospitaldDepartment of Cardiology, Nanjing Drum Tower Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
Journal:Medicine (Baltimore). 2017 Dec;96(49):e9179. doi: 10.1097/MD.0000000000009179.

6:Comparison of Oral Anticoagulants for Stroke Prevention in Nonvalvular Atrial Fibrillation: A Multicriteria Decision Analysis.
Authors:Tervonen T, Ustyugova A, Sri Bhashyam S, Lip GYH, Verdecchia P, Kwan R, Gropper S, Heinrich-Nols J, Marsh K
Institution:Evidera, London, UK. Electronic address: Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
Journal:Value Health. 2017 Dec;20(10):1394-1402. doi: 10.1016/j.jval.2017.06.006. Epub 2017 Jul 15.

7:Chocolate consumption and risk of atrial fibrillation: Two cohort studies and a meta-analysis.
Authors:Larsson SC, Drca N, Jensen-Urstad M, Wolk A
Institution:Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. Electronic address: Stockholm, Sweden. Stockholm, Sweden. Institutet, Stockholm, Sweden; Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Journal:Am Heart J. 2018 Jan;195:86-90. doi: 10.1016/j.ahj.2017.09.013. Epub 2017 Sep 21.

8:Predictors of perioperative major bleeding in patients who interrupt warfarin for an elective surgery or procedure: Analysis of the BRIDGE trial.
Authors:Clark NP, Douketis JD, Hasselblad V, Schulman S, Kindzelski AL, Ortel TL
Institution:Kaiser Permanente Colorado, Aurora, CO. Electronic address: Rockville, MD.
Journal:Am Heart J. 2018 Jan;195:108-114. doi: 10.1016/j.ahj.2017.09.015. Epub 2017 Sep 21.

9:Pharmacologic Prevention of Incident Atrial Fibrillation: Long-Term Results From the ALLHAT (Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial).
Authors:Dewland TA, Soliman EZ, Yamal JM, Davis BR, Alonso A, Albert CM, Simpson LM, Haywood LJ, Marcus GM
Institution:From the Knight Cardiovascular Institute, Oregon Health & Science University, Portland (T.A.D.); Cardiology Section, Department of Internal Medicine, Wake Forest School of Medicine, Winston Salem, NC (E.Z.S.); University of Texas School of Public Health, Houston (J.-M.Y., B.R.D., L.M.S.); Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA (A.A.); Center for Arrhythmia Prevention, Division of Preventive Medicine and Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (C.M.A.); Keck School of Medicine, University of Southern California, Los Angeles (L.J.H.); and Electrophysiology Section, Division of Cardiology, Department of Medicine, University of California, San Francisco (G.M.M.).
Journal:Circ Arrhythm Electrophysiol. 2017 Dec;10(12). pii: CIRCEP.117.005463. doi: 10.1161/CIRCEP.117.005463.

10:The Relationship Between Cardiologist Care and Clinical Outcomes in Patients With New-Onset Atrial Fibrillation.
Authors:Singh SM, Qiu F, Webster L, Austin PC, Ko DT, Tu JV, Wijeysundera HC
Institution:Schulich Heart Centre, Sunnybrook Health Sciences Centre, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. Electronic address:; Institute for Clinical Evaluative Sciences (ICES), Toronto, Ontario, Canada.; Schulich Heart Centre, Sunnybrook Health Sciences Centre, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Institute for Clinical Evaluative Sciences (ICES), Toronto, Ontario, Canada; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada.
Journal:Can J Cardiol. 2017 Dec;33(12):1693-1700. doi: 10.1016/j.cjca.2017.10.003.

11:Mechanisms, Clinical Significance, and Prevention of Cognitive Impairment in Patients With Atrial Fibrillation.
Authors:Rivard L, Khairy P
Institution:Department of Medicine, Montreal Heart Institute, Universite de Montreal, Montreal, Quebec, Canada. Electronic address: Montreal, Quebec, Canada.
Journal:Can J Cardiol. 2017 Dec;33(12):1556-1564. doi: 10.1016/j.cjca.2017.09.024. Epub 2017 Oct 6.

12:Outcomes of Dabigatran and Warfarin for Atrial Fibrillation in Contemporary Practice: A Retrospective Cohort Study.
Authors:Go AS, Singer DE, Toh S, Cheetham TC, Reichman ME, Graham DJ, Southworth MR, Zhang R, Izem R, Goulding MR, Houstoun M, Mott K, Sung SH, Gagne JJ
Institution:From Kaiser Permanente Northern California, Oakland, California, University of California, San Francisco, San Francisco, California, and Stanford University School of Medicine, Stanford, California; Massachusetts General Hospital, Boston, Massachusetts; Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts; Western University of Health Sciences College of Pharmacy, Pomona, California; U.S. Food and Drug Administration, Silver Spring, Maryland; and Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Journal:Ann Intern Med. 2017 Dec 19;167(12):845-854. doi: 10.7326/M16-1157. Epub 2017 Nov 14.

13:5-Year Outcomes After Left Atrial Appendage Closure: From the PREVAIL and PROTECT AF Trials.
Authors:Reddy VY, Doshi SK, Kar S, Gibson DN, Price MJ, Huber K, Horton RP, Buchbinder M, Neuzil P, Gordon NT, Holmes DR Jr.
Institution:Department of Cardiology, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Cardiology, Homolka Hospital, Prague, Czech Republic. Electronic address: Missouri.
Journal:J Am Coll Cardiol. 2017 Dec 19;70(24):2964-2975. doi: 10.1016/j.jacc.2017.10.021. Epub 2017 Nov 4.

14:High overall cardiovascular risk and mortality in patients with atrial fibrillation and diabetes: A nationwide report.
Authors:Karayiannides S, Lundman P, Friberg L, Norhammar A
Institution:1 Department of Clinical Sciences, Karolinska Institutet, Danderyd University Hospital, Stockholm, Sweden. Sweden. Hospital, Stockholm, Sweden. Hospital, Stockholm, Sweden. University Hospital, Stockholm, Sweden.
Journal:Diab Vasc Dis Res. 2018 Jan;15(1):31-38. doi: 10.1177/1479164117735013. Epub 2017 Oct 20.

15:Efficacy and safety of dronedarone in the treatment of patients with atrial fibrillation.
Authors:Khan MH, Rochlani Y, Aronow WS
Institution:a The Cardiology Division, Department of Medicine , Westchester Medical Center and New York Medical College , Valhalla , NY , USA.
Journal:Expert Opin Drug Saf. 2017 Dec;16(12):1407-1412. doi: 10.1080/14740338.2017.1387246. Epub 2017 Oct 6.

16:Integrated care in atrial fibrillation: a systematic review and meta-analysis.
Authors:Gallagher C, Elliott AD, Wong CX, Rangnekar G, Middeldorp ME, Mahajan R, Lau DH, Sanders P, Hendriks JML
Institution:Centre for Heart Rhythm Disorders, University of Adelaide, South Australian Health and Medical Research Institute and Royal Adelaide Hospital, Adelaide, Australia.
Journal:Heart. 2017 Dec;103(24):1947-1953. doi: 10.1136/heartjnl-2016-310952. Epub 2017 May 10.

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